Drew Endy Foundations for engineering biology
the four challenges that greatly limit engineering biology today are 1)biological complexity; 2)the tedious and unreliable construction and characterization of synthetic biological systems; 3)the spontaneous variation of biological systems; and 4) evolution.
Lessons from the past
standardization
Registry of Standard Biological Parts: http://parts.mit.edu/registry/index.php/Main_Page
decoupling;
separation of deign and implementation
for example, one group design useful DNA sequences and another group synthesize the piece of DNA chemically. (it seems possible now)
abstraction
design of reproducing machines
reliable computing with unreliable components
error detection & correction mechanism
self-replicating automata
additional reading:
Elowitz, M. B. & Leibler, S. A synthetic oscillatory network of transcriptional
regulators. Nature 403, 335–-338 (2000)
Sprinzak, D. & Elowitz, M. B. Reconstruction of genetic circuits. Nature
doi:10.1038/nature04335
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